Bryan Johnson Supplements List: Complete 2025 Guide

Introduction to Bryan Johnson's Approach to Supplements

Bryan Johnson, the tech entrepreneur and founder of Blueprint, is renowned for his extreme anti-aging protocol aimed at reversing biological age. Through his "Don't Die" philosophy, documented on his website, podcasts, and social media, Johnson invests millions annually in data-driven interventions to achieve superhuman health metrics. His supplement regimen is a cornerstone of this, involving over 100 daily pills, powders, and oils, personalized via biomarkers, AI analysis, and clinical trials. Johnson's stack evolves with new evidence — he's updated it in 2025 to emphasize NAD+ precursors, senolytics, and gut health while cycling prescriptions like metformin.

This guide compiles Bryan Johnson's 2025 supplements list, based on his official protocol and analyses, including dosages, timings, and rationales. Note: Johnson's routine includes Blueprint-branded bundles (e.g., Essentials, Longevity Mix) that encapsulate multiple compounds for convenience.

Why Does Bryan Johnson Take Supplements?

Johnson's approach is hyper-optimized for longevity, targeting cellular repair, inflammation, metabolism, and organ function. He uses 1,000+ biomarkers to adjust his stack, aiming for the "best biomarkers on Earth." Key principles:

• Evidence-Driven: Prioritizes RCTs, animal studies, and personal data (e.g., NMN for NAD+ based on human trials showing improved muscle function).
• Comprehensive Coverage: Addresses deficiencies, autophagy, senolytics, and more via 70+ compounds.
• Risk Management: Cycles items like metformin; monitors for side effects.
• Blueprint Integration: Bundles simplify intake, with third-party testing for purity.

In his protocol, supplements complement a 2,250-calorie vegan diet, sleep optimization, and therapies like HBOT.

Bryan Johnson's Daily Supplements List (2025 Update)

Johnson's stack totals ~100 pills, split by meals. Dosages are personalized — adjust via testing. Blueprint products are his brand unless noted.

Detailed Breakdown of Each Supplement

Longevity Precursors (NAD+, Autophagy)

NMN/NR and Spermidine boost cellular energy and renewal, backed by trials for muscle and aging. Ca-AKG and Fisetin target mitochondria and senescent cells.

Anti-Inflammatory/Antioxidants

Omega-3s, Curcumin, Ginger, and Garlic reduce inflammation; Vitamin C/E and Cocoa support oxidation defense.

Vitamins/Minerals

D3, K variants, Zinc, B Complex address deficiencies; monitored via labs.

Protein/Gut Support

Collagen, Creatine, Prebiotics like GOS/Inulin aid recovery and microbiome.

Prescriptions

Metformin/Acarbose for metabolism (cycled); others for specific conditions under physician supervision.

Supplements Bryan Johnson No Longer Takes

• PRP Injections: Discontinued for hair; no visible improvements.
• Resveratrol: Dropped due to insufficient evidence.
• High-Dose Certain Items: Adjusted based on 2025 biomarkers.

How to Optimize Your Own Supplement Routine Like Johnson

1. Biomarker Testing: Use labs for NAD+, inflammation (e.g., hs-CRP).
2. Quality Sources: Third-party tested; start with Blueprint bundles.
3. Gradual Introduction: Add one category weekly.
4. Track & Adjust: Apps for metrics; consult MD for Rx.
5. Lifestyle Synergy: Pair with calorie restriction, exercise.

Conclusion

Bryan Johnson's 2025 supplements list is a blueprint for radical longevity, blending science and self-experimentation. While extreme, it inspires personalized optimization. Follow his updates on blueprint.bryanjohnson.com for evolutions.

Last updated: September 30, 2025. Sources from Johnson's protocol and expert reviews. This is general wellness information, not medical advice — discuss any supplement changes with your healthcare provider.